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自体造血干细胞移植后多发性骨髓瘤患者中的小克隆T细胞：T-LGL白血病类型还是克隆性T细胞畸变？

Small-Sized Clone of T Cells in Multiple Myeloma Patient after Auto-SCT: T-LGL Leukemia Type or Clonal T-Cell Aberration?

作者信息

Mele Giuseppe, Greco Marilena, Coppi Maria Rosaria, Loseto Giacomo, Melpignano Angela, Mauro Salvatore, Quarta Gianni

机构信息

Haematology Division and BMT Unit, Antonio Perrino Hospital, 72100 Brindisi, Italy.

出版信息

Case Rep Hematol. 2013;2013:417353. doi: 10.1155/2013/417353. Epub 2013 Apr 21.

DOI:10.1155/2013/417353
PMID:23691376
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3652047/
Abstract

Second cancers and particularly postransplant lymphoproliferative disorders (PTLDs) are extremely rare in patients undergoing autologous peripheral blood stem cell transplantation (auto-SCT). We report the case of clonally rearranged T-cell expansion which occurred after auto-SCT for Multiple Myeloma (MM). Does asymptomatic clonal T-cell large granular lymphocytic proliferation, in our experience, represent either a secondary cancer after auto-SCT or clonal T cell aberration or derive from expansion of coexisting undetected small-sized clone of T cells?

摘要

在接受自体外周血干细胞移植（auto-SCT）的患者中，二次癌症尤其是移植后淋巴细胞增殖性疾病（PTLD）极为罕见。我们报告了一例多发性骨髓瘤（MM）患者在自体造血干细胞移植后发生克隆性重排的T细胞扩增的病例。根据我们的经验，无症状的克隆性T细胞大颗粒淋巴细胞增殖是自体造血干细胞移植后的二次癌症、克隆性T细胞畸变，还是源于未被检测到的共存小尺寸T细胞克隆的扩增？

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a51/3652047/88b46fe756a1/CRIM.HEMATOLOGY2013-417353.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a51/3652047/e4d1631ffa9f/CRIM.HEMATOLOGY2013-417353.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a51/3652047/88b46fe756a1/CRIM.HEMATOLOGY2013-417353.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a51/3652047/e4d1631ffa9f/CRIM.HEMATOLOGY2013-417353.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a51/3652047/88b46fe756a1/CRIM.HEMATOLOGY2013-417353.002.jpg

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Small-Sized Clone of T Cells in Multiple Myeloma Patient after Auto-SCT: T-LGL Leukemia Type or Clonal T-Cell Aberration?自体造血干细胞移植后多发性骨髓瘤患者中的小克隆T细胞：T-LGL白血病类型还是克隆性T细胞畸变？
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本文引用的文献

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Secondary primary malignancies in patients with multiple myeloma treated with high-dose chemotherapy and autologous blood stem cell transplantation.接受大剂量化疗和自体血干细胞移植治疗的多发性骨髓瘤患者的继发性原发性恶性肿瘤。
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T 细胞大颗粒淋巴细胞白血病：亚洲视角。
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An overview of the pathogenesis and natural history of post-transplant T-cell lymphoma (corrected and republished article originally printed in Leukemia & Lymphoma, June 2007; 48(6): 1237 - 1241).移植后T细胞淋巴瘤的发病机制与自然史概述（校正并重新发表的文章，最初发表于《白血病与淋巴瘤》，2007年6月；48(6): 1237 - 1241）
Leuk Lymphoma. 2007 Sep;48(9):1780-4. doi: 10.1080/10428190701608657.
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Post-transplant lymphoproliferative disorder.移植后淋巴细胞增生性疾病
Clin Chest Med. 2005 Dec;26(4):631-45, vii. doi: 10.1016/j.ccm.2005.06.014.
8
T-cell post-transplantation lymphoproliferative disorders after cardiac transplantation: a single institutional experience.心脏移植后T细胞移植后淋巴细胞增殖性疾病：单中心经验
Br J Haematol. 2004 Nov;127(4):429-32. doi: 10.1111/j.1365-2141.2004.05212.x.
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T-cell large granular lymphocytic leukemia occurring after autologous peripheral blood stem cell transplantation.
Bone Marrow Transplant. 2004 Jan;33(1):99-101. doi: 10.1038/sj.bmt.1704298.
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