Duminuco Andrea, Parisi Marina, Milone Giulio Antonio, Cupri Alessandra, Leotta Salvatore, Palumbo Giuseppe A, Parrinello Nunziatina Laura, Scuderi Grazia, Triolo Anna, Milone Giuseppe
Hematology Unit and Bone Marrow Transplant, A.O.U. Policlinico "G. Rodolico-San Marco", 95123 Catania, Italy.
Division of Hematology with BMT, Istituto Oncologico del Mediterraneo, 95029 Viagrande, Italy.
Hematol Rep. 2023 Oct 11;15(4):555-561. doi: 10.3390/hematolrep15040058.
Monoclonal T-cell lymphocytosis has been reported in patients with concomitant autoimmune diseases, viral infections, or immunodeficiencies. Referred to as T-cell large granular lymphocytic leukemia (T-LGLL), most cases cannot identify the triggering cause. Only small case series have been reported in the literature, and no treatment consensus exists. T-cell lymphocytosis may also appear after the transplant of hematopoietic stem cells or solid organs. Rare cases have been reported in patients undergoing autologous stem cell transplant (ASCT) for hematological diseases (including multiple myeloma or non-Hodgkin's lymphoma). Here, we describe the singular case of a patient who underwent ASCT for Hodgkin's lymphoma and displayed the onset of T-LGLL with an uncommonly high number of lymphocytes in peripheral blood and their subsequent spontaneous remission.
在患有自身免疫性疾病、病毒感染或免疫缺陷的患者中，曾有单克隆T细胞淋巴细胞增多症的报道。这种疾病被称为T细胞大颗粒淋巴细胞白血病（T-LGLL），大多数病例无法确定触发原因。文献中仅报道了少量病例系列，尚无治疗共识。T细胞淋巴细胞增多症也可能出现在造血干细胞或实体器官移植后。在接受血液系统疾病（包括多发性骨髓瘤或非霍奇金淋巴瘤）自体干细胞移植（ASCT）的患者中，也有罕见病例的报道。在此，我们描述了一例因霍奇金淋巴瘤接受ASCT的患者的特殊病例，该患者出现了外周血淋巴细胞数量异常高的T-LGLL发作，随后自发缓解。
