Cınar Yasin, Cingü Abdullah Kürşat, Sahin Alparslan, Türkcü Fatih Mehmet, Yüksel Harun, Caca Ihsan
Department of Ophthalmology, School of Medicine, Dicle University, Diyarbakir , Turkey.
Cutan Ocul Toxicol. 2014 Mar;33(1):28-31. doi: 10.3109/15569527.2013.793700. Epub 2013 May 21.
Abstract Objective: To monitor the changes in corneal thickness during the corneal collagen cross-linking procedure by using isotonic riboflavin solution without dextran in ectatic corneal diseases.
The corneal thickness measurements were obtained before epithelial removal, after epithelial removal, following the instillation of isotonic riboflavin solution without dextran for 30 min, and after 10 min of ultraviolet A irradiation.
Eleven eyes of eleven patients with progressive keratoconus (n = 10) and iatrogenic corneal ectasia (n = 1) were included in this study. The mean thinnest pachymetric measurements were 391.82 ± 30.34 µm (320-434 µm) after de-epithelialization of the cornea, 435 ± 21.17 µm (402-472 µm) following 30 min instillation of isotonic riboflavin solution without dextran and 431.73 ± 20.64 µm (387-461 µm) following 10 min of ultraviolet A irradiation to the cornea.
Performing corneal cross-linking procedure with isotonic riboflavin solution without dextran might not induce corneal thinning but a little swelling throughout the procedure.
摘要 目的：在扩张性角膜疾病中，使用不含右旋糖酐的等渗核黄素溶液监测角膜胶原交联过程中角膜厚度的变化。
在去除上皮前、去除上皮后、滴注不含右旋糖酐的等渗核黄素溶液30分钟后以及紫外线A照射10分钟后测量角膜厚度。
本研究纳入了11例患者的11只眼，其中进行性圆锥角膜患者10例，医源性角膜扩张患者1例。角膜去上皮后最薄角膜厚度的平均值为391.82±30.34µm（320 - 434µm），滴注不含右旋糖酐的等渗核黄素溶液30分钟后为435±21.17µm（402 - 472µm），角膜接受紫外线A照射10分钟后为431.73±20.64µm（387 - 461µm）。
使用不含右旋糖酐的等渗核黄素溶液进行角膜交联手术可能不会导致角膜变薄，而是在整个过程中出现轻微肿胀。
