Gendrel D, Verdier F, Richard-Lenoble D, Nardou M
Faculté de Médecine et des Sciences de la Santé, Libreville, Gabon.
Arch Fr Pediatr. 1990 May;47(5):387-8.
The plasma levels of chloroquine after an oral intake of 10 mg/kg were measured in 5 children, with or without simultaneous intake of cholestyramine. Plasma chloroquine levels measured 6 hours after intake were significantly lower in case of simultaneous administration of cholestyramine, in spite of important individual changes. These data suggest a decrease in chloroquine bioavailability in the presence of cholestyramine. However, the methodology used does not allow to assert it.
对5名儿童口服10毫克/千克氯喹后的血浆水平进行了测量，这些儿童同时或不同时服用考来烯胺。尽管个体差异较大，但在同时服用考来烯胺的情况下，摄入后6小时测得的血浆氯喹水平显著较低。这些数据表明考来烯胺存在时氯喹的生物利用度降低。然而，所采用的方法无法证实这一点。
