Hunninghake D B, King S, LaCroix K
Int J Clin Pharmacol Ther Toxicol. 1982 Apr;20(4):151-4.
The effect of cholestyramine and colestipol on the absorption of a single orally administered dose of 75 mg hydrochlorothiazide was determined. Both urinary excretion and plasma levels of hydrochlorothiazide were measured. Cholestyramine or colestipol administration decreased the total urinary excretion of hydrochlorothiazide by 85 and 43%, respectively. Similar effects were also noted on plasma hydrochlorothiazide levels.
测定了消胆胺和考来烯胺对单次口服75毫克氢氯噻嗪吸收的影响。同时测量了氢氯噻嗪的尿排泄量和血浆水平。服用消胆胺或考来烯胺分别使氢氯噻嗪的总尿排泄量减少了85%和43%。在血浆氢氯噻嗪水平上也观察到了类似的效果。
