Wohl Virion Centre, Division of Infection & Immunity, University College London, Gower Street, London WC1E, UK.
BMC Biol. 2013 May 21;11:57. doi: 10.1186/1741-7007-11-57.
During 30 years of research on human immunodeficiency virus (HIV), our knowledge of its cellular receptors--CD4, CCR5 and CXCR4--has illuminated aspects of the pathogenesis of the acquired immune deficiency syndrome (AIDS). Studying how the HIV envelope glycoproteins interact with the receptors led to anti-retroviral drugs based on blocking the docking or fusion of virus to the host cell. Genetic polymorphisms of CCR5 determine resistance to HIV infection and the rate of progression to AIDS. Eliciting neutralizing antibodies to the sites of receptor interaction on HIV glycoproteins is a promising approach to HIV vaccine development.
在对人类免疫缺陷病毒 (HIV) 进行 30 年的研究中，我们对其细胞受体——CD4、CCR5 和 CXCR4 的了解揭示了获得性免疫缺陷综合征 (AIDS) 发病机制的各个方面。研究 HIV 包膜糖蛋白如何与受体相互作用，导致了基于阻断病毒与宿主细胞对接或融合的抗逆转录病毒药物。CCR5 的遗传多态性决定了对 HIV 感染的抵抗力和发展为艾滋病的速度。针对 HIV 糖蛋白上受体相互作用位点产生中和抗体是 HIV 疫苗开发的一种有前途的方法。
