Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 2 Nanwei Rd., Xicheng District, Beijing, 100050, People's Republic of China.
Mol Divers. 2013 Aug;17(3):613-8. doi: 10.1007/s11030-013-9451-0. Epub 2013 May 22.
We report the synthesis of a tetrasaccharide with side chain using a light-fluorous-tagged glycosyl donor through the double glycosylation and gradient fluorous solid-phase extraction by adding a little of DCM to improve the solubility for retention for the first time. This convergent method has high efficacy by saving much time and solvent.
我们首次通过双糖苷化反应和梯度氟固相萃取（在氟固相萃取中加入少量二氯甲烷以提高溶解度和保留率），使用带有光氟化标记的糖基供体合成了带有侧链的四糖。这种收敛方法通过节省大量时间和溶剂，具有很高的功效。
