Kidney biopsies in control or cyclosporin A-treated psoriatic patients. International Kidney Biopsy Registry of Cyclosporin A (Sandimmun) in Autoimmune Diseases.

Kidney biopsies were obtained from 14 adult patients treated with cyclosporin A (CyA) for psoriasis. These biopsies were compared with those from 16 psoriatic patients of the same age, but who were not receiving treatment with CyA. Patients receiving CyA had a maximum mean dose of 5.1 mg/kg/day for a mean duration of 15 months (range 3-37 months). Minimal or slight interstitial fibrosis, tubular atrophy or arteriolopathy were seen in the biopsies of patients receiving CyA as well as in those of the controls. No relevant CyA-related structural alterations of the kidney were detected.