Lukashev V A, Kulichkov V A
Biofizika. 1990 Mar-Apr;35(2):236-41.
Frequency distributions of adjacent ARs in the primary structures of 320 globular proteins out of different superfamilies were investigated. ARs of every type were compared with the occurrence frequencies of 20 canonic residues at the distances of 1-20 residues according to their primary structure. Amino acid residues were found to be divided into groups of interchangeable residues in the course of globular protein evolution according to the distribution kinds and in terms of Euclidean distances. The use of pancreatic RNases of mammals showed that the approximate preservation of frequency adjacent (1-4 residues according to their primary structure) and characteristics in 5-15 residues mid-interactions may be used in studying the supposed amino acid substitutions in globular protein.
研究了不同超家族的320种球状蛋白质一级结构中相邻氨基酸替换（ARs）的频率分布。根据其一级结构，将每种类型的ARs与20种标准残基在1 - 20个残基距离处的出现频率进行比较。根据分布种类和欧几里得距离，发现氨基酸残基在球状蛋白质进化过程中被分为可互换残基组。对哺乳动物胰腺核糖核酸酶的研究表明，在研究球状蛋白质中假定的氨基酸替换时，可以利用一级结构中相邻（1 - 4个残基）频率的近似保留以及5 - 15个残基中间相互作用的特征。
