Poroĭkov V V, Esipova N G, Tumanian V G
Mol Biol (Mosk). 1984 Mar-Apr;18(2):541-7.
The amino acid composition and sequence in primary structure of 180 proteins have been studied. It is shown that the distribution of amino acid residues is near to a random one, i.e. it is determined by the amino acid composition. The ratio between statistical and unique character of protein primary structures has been discussed. The amino acid sequence is suggested to be unique in fibrous proteins. In contrast the amino acid sequence in globular proteins is a statistical one. The statistical character of amino acids distribution in globular proteins explains the possibility of sensible text generation under the frame shift mutations, deletions and insertions.
对180种蛋白质一级结构中的氨基酸组成和序列进行了研究。结果表明,氨基酸残基的分布接近随机分布,即由氨基酸组成决定。讨论了蛋白质一级结构的统计特征与独特特征之间的比例关系。有人认为纤维状蛋白质中的氨基酸序列是独特的。相比之下,球状蛋白质中的氨基酸序列是统计性的。球状蛋白质中氨基酸分布的统计特征解释了在移码突变、缺失和插入情况下产生合理文本的可能性。