Department of Anatomy and Neuroscience, University of Melbourne, Parkville, Melbourne, VIC, 3010, Australia.
Adv Exp Med Biol. 2013;786:1-4. doi: 10.1007/978-94-007-6621-1_1.
This volume describes the latest findings on transcriptional and translational regulation of stem cells. Both transcriptional activators and repressors have been shown to be crucial for the maintenance of the stem cell state. A key element of stem cell maintenance is repression of differentiation factors or developmental genes - achieved transcriptionally, epigenetically by the Polycomb complex, and post-transcriptionally by RNA-binding proteins and microRNAs. This volume takes two approaches to this topic - (1) illustrating the general principles outlined above through a series of different stem cell examples - embryonic, iPS and adult stem cells, and (2) describing several molecular families that have been shown to have roles in regulation of multiple stem cell populations.
本卷描述了关于干细胞转录和翻译调控的最新发现。转录激活因子和转录抑制因子都被证明对维持干细胞状态至关重要。维持干细胞的一个关键因素是抑制分化因子或发育基因 - 通过多梳复合物在转录水平上，通过表观遗传修饰，以及通过 RNA 结合蛋白和 microRNAs 在转录后水平上实现。本卷通过一系列不同的干细胞实例（胚胎干细胞、iPS 细胞和成人干细胞）采用两种方法来探讨这个主题 - （1）通过一系列不同的干细胞实例（胚胎干细胞、iPS 细胞和成人干细胞）来阐述上述一般原则，以及（2）描述几个已经被证明在多个干细胞群体的调控中具有作用的分子家族。
