Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, RTP, NC, United States.
Curr Opin Genet Dev. 2017 Oct;46:15-23. doi: 10.1016/j.gde.2017.06.010. Epub 2017 Jun 24.
Pluripotency describes the developmental capacity to give rise to all cell types in the adult body. A comprehensive understanding of the molecular mechanisms that regulate pluripotency is important for both basic and translational research. While earlier studies mostly focused on signaling pathways, transcriptional regulation, and epigenetic modifications, recent investigations showed that RNA binding proteins, RNA processing machineries, and regulatory RNA molecules also play essential roles. Here, we provide a concise review on the latest findings and developments in post-transcriptional regulation of the pluripotent state.
多能性描述了产生成体体内所有细胞类型的发育能力。全面了解调控多能性的分子机制对于基础研究和转化研究都很重要。虽然早期的研究主要集中在信号通路、转录调控和表观遗传修饰上，但最近的研究表明，RNA 结合蛋白、RNA 处理机制和调节性 RNA 分子也起着至关重要的作用。在这里，我们提供了一个关于多能状态的转录后调控的最新发现和进展的简要综述。
