Department of Psychological Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.
J Trauma Stress. 2013 Jun;26(3):299-309. doi: 10.1002/jts.21814. Epub 2013 May 20.
Although co-occurring posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) is associated with greater distress, impairment, and health care utilization than PTSD alone, the magnitude of this problem is uncertain. This meta-analysis aimed to estimate the mean prevalence of current MDD co-occurrence among individuals with PTSD and examine potential moderating variables (U.S. nationality, gender, trauma type, military service, referral type) that may influence the rate of PTSD and MDD co-occurrence. Meta-analytic findings (k = 57 studies; N = 6,670 participants) revealed that 52%, 95% confidence interval [48, 56], of individuals with current PTSD had co-occurring MDD. When outliers were removed, military samples and interpersonal traumas demonstrated higher rates of MDD among individuals with PTSD than civilian samples and natural disasters, respectively. U.S. nationality, gender, and referral type did not significantly account for differences in co-occurrence rates. This high co-occurrence rate accentuates the importance of routinely assessing MDD among individuals with PTSD and continuing research into the association between these disorders.
尽管创伤后应激障碍 (PTSD) 和重度抑郁障碍 (MDD) 同时存在与单纯 PTSD 相比，会导致更大的痛苦、损伤和医疗保健利用，但这一问题的严重程度尚不确定。本荟萃分析旨在估计 PTSD 患者中当前 MDD 共病的平均患病率，并探讨可能影响 PTSD 和 MDD 共病发生率的潜在调节变量（美国国籍、性别、创伤类型、兵役、转诊类型）。荟萃分析结果（k = 57 项研究；N = 6670 名参与者）显示，当前患有 PTSD 的个体中有 52%（95%置信区间 [48, 56]）同时患有 MDD。当排除异常值后，与自然灾害相比，军事样本和人际创伤导致 PTSD 患者中 MDD 的发生率更高。美国国籍、性别和转诊类型并不能显著解释共病率的差异。这种高共病率凸显了在 PTSD 患者中常规评估 MDD 的重要性，并继续研究这些疾病之间的关联。
