Claxton Jade, Alberici Alice, Meiser-Stedman Richard, Chiu Henry Tak Shing
Department of Clinical Psychology and Psychological Therapies, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK.
Eur J Psychotraumatol. 2025 Dec;16(1):2527550. doi: 10.1080/20008066.2025.2527550. Epub 2025 Jul 30.
Depression and Post Traumatic Stress Disorder (PTSD) are highly comorbid disorders following trauma exposure; when comorbid they are associated with more deleterious and long-term impact. However, the nature of this relationship lacks consensus and is understudied in adolescence, despite this being highlighted as a critical period for trauma exposure. Cognitive processes such as appraisals, avoidance and rumination have been implicated in both disorders separately and could be potential shared mechanisms underlying this comorbidity.
In a cross-sectional design, 280 secondary school pupils (12-15 years), reporting trauma exposure, completed self-report measures of Post Traumatic Stress Symptoms (PTSS), depression and maladaptive cognitive processes (trauma-related and depressogenic appraisals, cognitive avoidance and rumination).
PTSS and depression symptoms were highly correlated ( = 0.79) and 60-65% of all probable diagnostic cases of PTSD or depression were comorbid. Strong positive correlations were found for negative trauma appraisals, depressogenic appraisals, cognitive avoidance and rumination, with statistically comparable strengths found for both PTSS and depression symptoms. Comparisons of probable diagnostic groups showed all groups endorsed all maladaptive processes although the comorbid group showed the greatest endorsement (and symptomology). Stepwise hierarchical regression models of the maladaptive processes explained 75-77% of the variance. Trauma-related appraisals were found most prominent in predicting both PTSS and depression symptoms although a commonality analysis suggested the interplay between all cognitive variables explained the vast amount of variance.
Cognitive appraisals, cognitive avoidance and rumination appear to be shared cognitive vulnerabilities in PTSD and depression, which may underlie PTSD-depression comorbidity and provide targets for intervention.
抑郁症和创伤后应激障碍(PTSD)是创伤暴露后高度共病的疾病;当两者共病时,它们会产生更有害和长期的影响。然而,这种关系的本质尚未达成共识,在青少年中也未得到充分研究,尽管这一时期被强调为创伤暴露的关键时期。诸如评估、回避和沉思等认知过程已分别与这两种疾病相关,可能是这种共病潜在的共同机制。
在一项横断面设计中,280名报告有创伤暴露的中学生(12 - 15岁)完成了创伤后应激症状(PTSS)、抑郁和适应不良认知过程(与创伤相关的和致抑郁的评估、认知回避和沉思)的自我报告测量。
PTSS和抑郁症状高度相关(= 0.79),所有可能诊断为PTSD或抑郁症的病例中有60 - 65%是共病的。在负性创伤评估、致抑郁评估、认知回避和沉思方面发现了强正相关,PTSS和抑郁症状的相关强度在统计学上相当。可能诊断组的比较表明,所有组都认可所有适应不良过程,尽管共病组的认可程度最高(以及症状表现)。适应不良过程的逐步分层回归模型解释了75 - 77%的方差。发现与创伤相关的评估在预测PTSS和抑郁症状方面最为突出,尽管共性分析表明所有认知变量之间的相互作用解释了大量方差。
认知评估、认知回避和沉思似乎是PTSD和抑郁症共有的认知脆弱性,这可能是PTSD - 抑郁症共病的基础,并为干预提供靶点。