对不同脂质组成的含血红蛋白脂质体悬浮液的粘度测量。
Viscosity measurements of suspensions of hemoglobin-containing liposomes of varying lipid composition.
作者信息
Jopski B, Pirkl V, Schmidt K H
机构信息
Chirurgische Klinik, Universität Tübingen, F.R.G.
出版信息
Biomater Artif Cells Artif Organs. 1990;18(2):345-58. doi: 10.3109/10731199009117312.
The viscosity of suspensions of hemoglobin-containing liposomes (Hb liposomes) and of liposomes without Hb was determined as a function of the shear rate. Liposomes of varying lipid composition were prepared by detergent dialysis. All liposome suspensions showed non-Newtonian viscous behavior, as did erythrocyte suspensions. The viscosity of suspensions of Hb liposomes with a bilayer consisting of egg yolk lecithin and phosphatidylserine was almost identical to erythrocyte suspension viscosity. When cholesterol was included in the lipid component of the Hb liposomes, the dependence of viscosity on the shear rate decreased (flattening of the curve), but overall suspension viscosity became higher than that of erythrocyte suspensions. Evidence is provided for the lipid concentration at which liposomes can be applied intravenously.
测定了含血红蛋白脂质体（Hb脂质体）和不含Hb的脂质体悬浮液的粘度与剪切速率的函数关系。通过去污剂透析制备了不同脂质组成的脂质体。所有脂质体悬浮液均表现出非牛顿粘性行为，红细胞悬浮液也是如此。由蛋黄卵磷脂和磷脂酰丝氨酸组成双层的Hb脂质体悬浮液的粘度几乎与红细胞悬浮液的粘度相同。当胆固醇包含在Hb脂质体的脂质成分中时，粘度对剪切速率的依赖性降低（曲线变平），但总体悬浮液粘度变得高于红细胞悬浮液。提供了脂质体可静脉内应用的脂质浓度的证据。
Zotero 插件