伊朗北部成年人的肥胖与高胆固醇血症风险

Obesity and risk of hypercholesterolemia in Iranian northern adults.

作者信息

Veghari Gholamreza, Sedaghat Mehdi, Joshghani Hamidraza, Banihashem Samieh, Moharloei Pooneh, Angizeh Abdolhamid, Tazik Ebrahim, Moghaddami Abbas

机构信息

Assistant Professor, Ischemic Disorders Research Center, School of Medicine, Golestan University of Medical Sciences, Golestan, Iran.

出版信息

ARYA Atheroscler. 2013 Jan;9(1):2-6.

PMID:23696752

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3653268/

Abstract

BACKGROUND

The main aim of this study was to evaluate the association between serum cholesterol level and body mass index (BMI) in northern Iran.

METHODS

This was a cross-sectional study carried out on the 1995 subjects (997 males and 998 females) aged 25-65 years that were selected using multistage cluster sampling method. Plasma cholesterol was measured in the morning after a 12-hour fasting and was determined by auto-analyzer. Hypercholesterolemia (HC) was defined by a total plasma cholesterol level over 200 mg/dl. Weight and height were measured and BMI 25-29.9 kg/m2 and ≥ 30 kg/m2 was classified overweight and obesity, respectively.

RESULTS

Mean of age was 44.2 ± 11.5 years (44.3 ± 11.5 in men and 44.1 ± 11.2 in women) and plasma total cholesterol level was 203.1 ± 41.8 mg/dl. The HC was detected in 49.1% with higher rate in women (57.0%) than men (44.7%). In men at age 25-35 years, the odds ratio was 3.42 (1.60-7.29) in obese group and 1.90 (1.03-3.50) in overweight group compared to normal weight. In women, at age 35-45 years, the risk of HC in obese group was 3.01 (1.58-5.73) and in overweight group it was 2.06 (1.58-5.73), while in men aged 35-45 years the relative risk was 4.03 (2.22-7.34) in overweight and 3.58 (1.77-7.25) in obese group. In women after age 45 years, higher BMI was not a risk factor for HC.

CONCLUSION

There was a positive association between BMI and serum cholesterol level. In early middle age, obese individuals were at risk of HC more than overweight subjects. In men, after age 35 years, the risk of HC increased in overweight group while in women there was no statistically significant association between BMI and HC.

摘要

背景

本研究的主要目的是评估伊朗北部血清胆固醇水平与体重指数（BMI）之间的关联。

方法

这是一项横断面研究，对1995名年龄在25至65岁之间的受试者（997名男性和998名女性）采用多阶段整群抽样方法进行选择。在禁食12小时后的早晨测量血浆胆固醇，并通过自动分析仪进行测定。高胆固醇血症（HC）定义为血浆总胆固醇水平超过200mg/dl。测量体重和身高，BMI在25至29.9kg/m²以及≥30kg/m²分别被分类为超重和肥胖。

结果

平均年龄为44.2±11.5岁（男性为44.3±11.5岁，女性为44.1±11.2岁），血浆总胆固醇水平为203.1±41.8mg/dl。检测到49.1%的人患有高胆固醇血症，女性（57.0%）的患病率高于男性（44.7%）。在25至35岁的男性中，与正常体重相比，肥胖组的优势比为3.42（1.60 - 7.29），超重组为1.90（1.03 - 3.50）。在女性中，35至45岁时，肥胖组患高胆固醇血症的风险为3.01（1.58 - 5.73），超重组为2.06（1.58 - 5.73），而在35至45岁的男性中，超重组的相对风险为4.03（2.22 - 7.34），肥胖组为3.58（1.77 - 7.25）。在45岁以后的女性中，较高的BMI不是高胆固醇血症的危险因素。