Baglin T P, Harper P, Marcus R E
Department of Haematology, Addenbrooke's Hospital, Cambridge, UK.
Bone Marrow Transplant. 1990 Jun;5(6):439-41.
A 45-year-old man underwent autologous bone marrow transplantation for relapsed myeloma. The procedure was complicated by the development of veno-occlusive disease (VOD) of the liver. Thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) resulted in rapid resolution of hepatic encephalopathy and ascites with improvement in liver function. The use of rt-PA in the management of VOD appears effective and should be evaluated in further patients.
一名45岁男性因复发性骨髓瘤接受了自体骨髓移植。该手术因发生肝静脉闭塞性疾病（VOD）而变得复杂。使用重组组织型纤溶酶原激活剂（rt-PA）进行溶栓治疗后，肝性脑病和腹水迅速消退，肝功能得到改善。rt-PA用于VOD的治疗似乎有效，应在更多患者中进行评估。
