Zhang Man, Zhu Si-Yuan, Li Qing-Mei, Shen Jing-Ling
Beijing Key Laboratory for Terahertz Spectroscopy and Imaging, Key Laboratory of Terahertz Optoelectronics, Ministry of Education, Department of Physics, Capital Normal University, Beijing 100048, China.
Guang Pu Xue Yu Guang Pu Fen Xi. 2013 Feb;33(2):330-3.
Terahertz Time-Domain Spectroscopy (THz-TDS) technique has a wide range of applications in substances identification and quantitative analysis. In the present paper, we report absorption spectra and index of refraction of 14 kinds of pure cephalosporins in 0.2-2.6 THz, in which eight kinds have apparent absorption peaks, while the others have different index of refraction. Based on these results, different kinds of antibiotics can be identified. Besides, according to THz absorption spectra of both pure sample and real pills we calculated the contents of cefixime in the two pills produced by two manufacturers. Compared with the contents marked on the package, relative errors are 9.38% and 0.92%, respectively. The results manifest that THz-TDS technique is reliable and promising in medicine detection.
太赫兹时域光谱（THz-TDS）技术在物质识别和定量分析方面有着广泛的应用。在本文中，我们报道了14种纯头孢菌素在0.2 - 2.6太赫兹范围内的吸收光谱和折射率，其中8种有明显的吸收峰，而其他的有不同的折射率。基于这些结果，可以识别不同种类的抗生素。此外，根据纯样品和实际药丸的太赫兹吸收光谱，我们计算了两个制造商生产的两种药丸中头孢克肟的含量。与包装上标注的含量相比，相对误差分别为9.38%和0.92%。结果表明，太赫兹时域光谱技术在药物检测中是可靠且有前景的。
