Tesar V, Kotal P, Petrtýl J, Bukovská J, Kozáková M, Brodanová M, Horký K, Kordac V
I. interní katedra fakulty vseobecného lékarství Univerzity Karlovy, Praha.
Cas Lek Cesk. 1990 May 25;129(21):657-64.
12 patients with cirrhosis of the liver (6 with ascites) and 6 control persons were given 80 mg furosemide intravenously and were followed up for pharmacokinetic, renal and haemodynamic effects. The patients with ascitic cirrhosis (AC) and the control persons were found to have the same plasma furosemide concentrations; however, the AC patients excreted significantly less furosemide into the urine in an 8-hour period than the control persons, which was due especially to lower urine furosemide excretion during the first hour after application in comparison with the control group (75 +/- 6.8 vs. 100.8 +/- 8.8 mumol/h, p less than 0.05). During the first post-furosemide hour, the AC patients had a significantly lower diuresis (13.3 +/- 2.4 vs. 23.9 +/- 1.1 ml/min, p less than 0.01) as well as natriuresis (1367.4 +/- 771.4 vs. 3242 +/- 137.5 mumol/min, p less than 0.01) than the control group and a significantly lower excretion fraction of sodium than the patients with live cirrhosis without ascites (6.5 +/- 0.8 vs. 10.7 +/- 1.5%, p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
对12例肝硬化患者（6例有腹水）和6名对照者静脉注射80毫克速尿，并对其药代动力学、肾脏和血流动力学效应进行随访。发现腹水型肝硬化（AC）患者和对照者的血浆速尿浓度相同；然而，AC患者在8小时内尿中速尿排泄量明显低于对照者，这尤其归因于与对照组相比，用药后第一小时尿中速尿排泄量较低（75±6.8对100.8±8.8微摩尔/小时，p<0.05）。在速尿用药后的第一小时，AC患者的利尿作用（13.3±2.4对23.9±1.1毫升/分钟，p<0.01）以及利钠作用（1367.4±771.4对3242±137.5微摩尔/分钟，p<0.01）明显低于对照组，且钠排泄分数明显低于无腹水的肝硬化患者（6.5±0.8对10.7±1.5%，p<0.05）。（摘要截短至250字）
