October 6 University, Urology, Cairo, Egypt.
Aging Male. 2013 Sep;16(3):108-11. doi: 10.3109/13685538.2013.795532. Epub 2013 May 22.
The current study was carried out to investigate the impact of atherosclerosis on lower urinary tract function in the male patients with lower urinary tract symptoms (LUTS).
This prospective study evaluated 110 male patients aged 55-75 years who were presented with LUTS. All patients underwent general and local investigations. The atherosclerosis was assessed by ultrasound examination of the carotid artery. Patients then were divided into two groups: non-atherosclerosis group (Group 1) and atherosclerosis group (Group 2). The two groups were compared regarding voiding and storage parameters.
Mean patient age were 67.9 ± 5.9 years. The average age and number of Group 1 was 65.7 ± 4.3, n = 51. The average age and number of Group 2 was 68.7 ± 5.3, n = 59. There were no significant differences in age, prostate volume, blood pressure, International Prostate Symptom Score, Voiding symptom score and Storage symptom score between the two groups. Blood serum triglycerides were significantly lower in Group 1 than Group 2 while HDL cholesterol were significantly higher in Group 1 than Group 2 0.97 ± 0.5 and 1.43 ± 0.2 mmol/L, versus 1.46 ± 0.7 and 1.28 ± 0.3 mmol/L, respectively. Qmax denotes significant decrease in Group 2 compared with Group 1 12.5 ± 6.3 versus 17.6 ± 6.5, respectively (p < 0.01). While in post-voiding residual urine, there was a significant increase in Group 2 compared with Group 1 82.2 ± 15.4 versus 51.4 ± 12.7, respectively (p < 0.01). Daytime voided urine denotes a significant decrease in Group 2 176 ± 48, compared with Group 1 221.2 ± 79 (p < 0.01). Daytime frequency and nocturia, were significantly higher in Group 2, compared with Group 1 8.90 ± 2.8 versus 7.16 ± 3.11, respectively, and 3.1 ± 1.2 versus 1.92 ± 1.12, respectively (p < 0.05).
The atherosclerosis disease play a significant role in the impairments of both voiding and storage function in male patients with LUTS irrelevant to the age.
本研究旨在探讨动脉粥样硬化对男性下尿路症状（LUTS）患者下尿路功能的影响。
本前瞻性研究评估了 110 名年龄在 55-75 岁之间出现 LUTS 的男性患者。所有患者均接受了一般和局部检查。通过颈动脉超声检查评估动脉粥样硬化。然后，患者被分为两组：非动脉粥样硬化组（第 1 组）和动脉粥样硬化组（第 2 组）。比较两组排尿和储存参数。
患者平均年龄为 67.9±5.9 岁。第 1 组的平均年龄和例数为 65.7±4.3，n=51；第 2 组的平均年龄和例数为 68.7±5.3，n=59。两组间年龄、前列腺体积、血压、国际前列腺症状评分、排尿症状评分和储存症状评分无显著差异。第 1 组血清甘油三酯明显低于第 2 组，而高密度脂蛋白胆固醇明显高于第 2 组，分别为 0.97±0.5 和 1.43±0.2mmol/L，而第 2 组为 1.46±0.7 和 1.28±0.3mmol/L。第 2 组 Qmax 明显低于第 1 组，分别为 12.5±6.3 和 17.6±6.5（p<0.01）。而在残余尿量方面，第 2 组明显高于第 1 组，分别为 82.2±15.4 和 51.4±12.7（p<0.01）。第 2 组日间排尿量明显减少，分别为 176±48，而第 1 组为 221.2±79（p<0.01）。日间频率和夜间多尿，第 2 组明显高于第 1 组，分别为 8.90±2.8 和 7.16±3.11，以及 3.1±1.2 和 1.92±1.12（p<0.05）。
动脉粥样硬化疾病在男性 LUTS 患者排尿和储存功能障碍中起重要作用，与年龄无关。
