Bang Woo Jin, Lee Joo Yong, Koo Kyo Chul, Hah Yoon Soo, Lee Dae Hun, Cho Kang Su
Department of Urology, Hallym University College of Medicine, Chuncheon, Korea.
Department of Urology, Severance Hospital, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.
Urology. 2014 Sep;84(3):670-4. doi: 10.1016/j.urology.2014.05.017.
To elucidate the relationship between type-2 diabetes mellitus (DM) and overactive bladder symptoms in men with lower urinary tract symptoms (LUTS), after adjusting for the impact of age and prostate volume.
Data were obtained from a prospectively maintained database of 905 first-visit patients with LUTS and benign prostatic hyperplasia. After excluding those with comorbidities that may affect urinary symptom, we selected 139 patients with type-2 DM and 139 nondiabetic controls matched by propensity scoring for age and prostate volume.
There were no differences in voided volume and maximal flow rate between the 2 groups, whereas residual urine volume was significantly higher in DM patients than controls (29.34 ± 26.99 mL vs 22.45 ± 23.25 mL; P = .028). The total International Prostatic Symptom Score was significantly higher in DM patients than controls (17.80 ± 7.60 vs 15.88 ± 7.05; P = .031). Storage (7.45 ± 3.21 vs 6.58 ± 3.11; P = .024) and postmicturition (2.57 ± 1.49 vs 2.19 ± 1.59; P = .045) symptom scores were higher in DM patients than controls, whereas the groups had similar voiding symptom scores (P = .104). Among storage symptoms, DM patients had higher frequency (P = .010) and nocturia (P = .003) scores but similar urgency scores. The Overactive Bladder Symptom Score was also significantly higher in DM patients; this difference was due to a higher nocturia (but not urgency) score.
DM patients with LUTS and benign prostatic hyperplasia had greater storage and postmicturition symptoms than age and prostate volume-matched controls. The disparity in storage symptoms was mainly because of frequency and nocturia rather than urgency.
在调整年龄和前列腺体积的影响后，阐明2型糖尿病（DM）与下尿路症状（LUTS）男性患者膀胱过度活动症状之间的关系。
数据来自一个前瞻性维护的数据库，该数据库包含905例初诊LUTS和良性前列腺增生患者。在排除可能影响尿路症状的合并症患者后，我们通过倾向评分法选择了139例2型糖尿病患者和139例年龄及前列腺体积匹配的非糖尿病对照。
两组间排尿量和最大尿流率无差异，而糖尿病患者的残余尿量显著高于对照组（29.34±26.99 mL对22.45±23.25 mL；P = 0.028）。糖尿病患者的国际前列腺症状总分显著高于对照组（17.80±7.60对15.88±7.05；P = 0.031）。糖尿病患者的储尿期（7.45±3.21对6.58±3.11；P = 0.024）和排尿后（2.57±1.49对2.19±1.59；P = 0.045）症状评分高于对照组，而两组的排尿症状评分相似（P = 0.104）。在储尿期症状中，糖尿病患者的尿频（P = 0.010）和夜尿（P = 0.003）评分较高，但尿急评分相似。膀胱过度活动症状评分在糖尿病患者中也显著更高；这种差异是由于夜尿（而非尿急）评分较高。
患有LUTS和良性前列腺增生的糖尿病患者比年龄及前列腺体积匹配的对照组有更严重的储尿期和排尿后症状。储尿期症状的差异主要是由于尿频和夜尿，而非尿急。
