Povýsil C, Sotorník I, Válek A
II. patologicko-anatomický ústav FVL KU, Praha.
Cesk Patol. 1990 May;26(2):65-71.
Histochemical study of 155 bone biopsies from dialyzed patients revealed 43 cases with aluminium deposits in bone trabeculae localized along the mineralization line or in phagolysosomes of bone marrow macrophages. Aluminium was limited to macrophages in 5 cases, to mineralization line in 23 cases, and found in both localities in 15 patients. Patients with a positive finding mostly had osteomalacia (8 times) which was combined in some cases (35 times) with mild fibrous osteodystrophy. Authors failed to prove histochemically positive deposits in dialyzed patients with serious parathyroidism. Simultaneous deposits of aluminium and hemosiderin were found in the mineralization line in three patients. Bone deposition of aluminium seems to influence somehow the bone lesion but precise interpretation of the phenomenon has not been given.
对155例透析患者的骨活检进行组织化学研究发现，43例患者的骨小梁中有铝沉积，这些沉积位于矿化线处或骨髓巨噬细胞的吞噬溶酶体中。5例患者的铝仅局限于巨噬细胞，23例患者的铝仅存在于矿化线，15例患者在这两个部位均发现有铝。有阳性发现的患者大多患有骨软化症（8例），部分病例（35例）合并轻度纤维性骨营养不良。作者未能通过组织化学方法在严重甲状旁腺功能亢进的透析患者中证实有阳性沉积物。3例患者在矿化线处同时发现有铝和含铁血黄素沉积。铝在骨中的沉积似乎以某种方式影响骨病变，但尚未对该现象作出确切解释。
