Charhon S A, Chapuy M C, Traeger J, Meunier P J
Presse Med. 1984 Jun 2;13(23):1431-4.
Four patients under maintenance dialysis for chronic renal failure were suffering from aluminium toxicity. One showed evidence of encephalopathy, two presented with fractures and one was asymptomatic. Hypercalcaemia was constant, whereas high serum aluminium levels were present in only 2 patients. In all cases, iliac bone biopsy specimens, non-decalcified and stained with Aluminium , were found to contain aluminium deposits along the mineralization fronts, thus confirming the diagnosis of aluminium overload. In addition, biopsies revealed an excess of osteoid tissue with morphological and dynamic signs of osteomalacia (2 cases) or strongly depressed bone formation (2 cases). Histomorphometric bone biopsy appears to be the best mean of diagnosing aluminium intoxication and analyzing its effects on bone remodeling and mineralization. It is also very useful to monitor the treatment.
四名因慢性肾衰竭接受维持性透析的患者出现了铝中毒。一名患者有脑病迹象，两名患者出现骨折，一名患者无症状。高钙血症持续存在，而仅2名患者血清铝水平升高。在所有病例中，髂骨活检标本经非脱钙处理并用铝染色后，发现沿矿化前沿有铝沉积，从而证实了铝过载的诊断。此外，活检显示类骨质组织过多，有骨软化的形态学和动力学迹象（2例）或骨形成严重受抑（2例）。组织形态计量学骨活检似乎是诊断铝中毒并分析其对骨重塑和矿化影响的最佳方法。它对监测治疗也非常有用。
