Skoczyński Mariusz, Goździcka-Józefiak Anna, Kwaśniewska Anna
Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin , Lublin , Poland and.
J Matern Fetal Neonatal Med. 2014 Feb;27(3):239-42. doi: 10.3109/14767058.2013.807238. Epub 2013 Jun 21.
The aim of this study was to analyze the relationship between the frequency of Human Papilloma Virus (HPV) isolation in pregnant women and their offspring, and to assess the risk of maternal-neonatal transmission.
The study included vaginal/buccal smears of 135 pregnant women, as well as the buccal smears and the respiratory discharge samples from their neonates. The material was tested for the presence of HPV DNA by means of PCR.
Twenty-two HPV 11-positive cases (16.3%) were detected amongst pregnant women, along with 16 neonatal HPV 11-positive cases (11.85%). The concordance rate of maternal and neonatal HPV 11 DNA was 54.5%. Three maternal variables: the presence of HPV 11, less than 10 years of education, and common law proved significant risk factors for vertical transmission.
Asymptomatic HPV infection of a pregnant woman rather than the mode of delivery or other obstetrical characteristics constitutes significant risk factor of vertical transmission.
本研究旨在分析孕妇人乳头瘤病毒（HPV）分离频率与其后代之间的关系，并评估母婴传播风险。
该研究纳入了135名孕妇的阴道/口腔涂片，以及其新生儿的口腔涂片和呼吸道分泌物样本。通过聚合酶链反应（PCR）检测材料中HPV DNA的存在情况。
在孕妇中检测到22例HPV 11阳性病例（16.3%），同时在新生儿中检测到16例HPV 11阳性病例（11.85%）。母婴HPV 11 DNA的一致性率为54.5%。三个母体变量：HPV 11的存在、受教育年限少于10年以及普通法被证明是垂直传播的重要风险因素。
孕妇无症状HPV感染而非分娩方式或其他产科特征是垂直传播的重要风险因素。
