Institute for Research in Biomedicine, Baldiri Reixac 10, Barcelona 08028, Spain.
Mar Drugs. 2013 May 21;11(5):1693-717. doi: 10.3390/md11051693.
Since the late 1980s, a large number of depsipeptides that contain a new topography, referred to as "head-to-side-chain" cyclodepsipeptides, have been isolated and characterized. These peptides present a unique structural arrangement that comprises a macrocyclic region closed through an ester bond between the C-terminus and a β-hydroxyl group, and terminated with a polyketide moiety or a more simple branched aliphatic acid. This structural pattern, the presence of unique and complex residues, and relevant bioactivity are the main features shared by all the members of this new class of depsipeptides, which are reviewed herein.
自 20 世纪 80 年代末以来，已经分离和鉴定了大量含有新型拓扑结构的环二肽，称为“头到侧链”环二肽。这些肽呈现出独特的结构排列，包括通过 C 末端和β-羟基之间的酯键封闭的大环区域，并以聚酮部分或更简单的支链脂肪酸为末端。这种结构模式、独特而复杂的残基的存在以及相关的生物活性是该新型环二肽所有成员的主要特征，本文对此进行了综述。
