Center for Chemical Biology and Biotechnology (C2B2), University of San Agustin, Iloilo City 5000, Philippines.
Department of Biology, University of San Agustin, Iloilo City 5000, Philippines.
Mar Drugs. 2024 Feb 28;22(3):114. doi: 10.3390/md22030114.
Extensive research has been conducted on the isolation and study of bioactive compounds derived from marine sources. Several natural products have demonstrated potential as inducers of apoptosis and are currently under investigation in clinical trials. These marine-derived compounds selectively interact with extrinsic and intrinsic apoptotic pathways using a variety of molecular mechanisms, resulting in cell shrinkage, chromatin condensation, cytoplasmic blebs, apoptotic bodies, and phagocytosis by adjacent parenchymal cells, neoplastic cells, or macrophages. Numerous marine-derived compounds are currently undergoing rigorous examination for their potential application in cancer therapy. This review examines a total of 21 marine-derived compounds, along with their synthetic derivatives, sourced from marine organisms such as sponges, corals, tunicates, mollusks, ascidians, algae, cyanobacteria, fungi, and actinobacteria. These compounds are currently undergoing preclinical and clinical trials to evaluate their potential as apoptosis inducers for the treatment of different types of cancer. This review further examined the compound's properties and mode of action, preclinical investigations, clinical trial studies on single or combination therapy, and the prospective development of marine-derived anticancer therapies.
已经进行了广泛的研究，以分离和研究源自海洋的生物活性化合物。一些天然产物已被证明具有诱导细胞凋亡的潜力，目前正在临床试验中进行研究。这些源自海洋的化合物通过多种分子机制选择性地与外在和内在凋亡途径相互作用，导致细胞收缩、染色质浓缩、细胞质泡、凋亡小体以及邻近实质细胞、肿瘤细胞或巨噬细胞的吞噬作用。目前，许多源自海洋的化合物正在接受严格检查，以评估其在癌症治疗中的潜在应用。本综述共检查了 21 种源自海洋的化合物及其合成衍生物，这些化合物源自海绵、珊瑚、被囊动物、软体动物、尾索动物、藻类、蓝细菌、真菌和放线菌等海洋生物。这些化合物目前正在进行临床前和临床试验，以评估它们作为诱导细胞凋亡的药物治疗不同类型癌症的潜力。本综述还进一步检查了化合物的性质和作用方式、临床前研究、单一或联合治疗的临床试验研究以及海洋来源的抗癌疗法的未来发展。
