Salviati M, Pallagrosi M, Valeriani G, Carlone C, Todini L, Biondi M
Department of Neurology and Psychiatry, Sapienza University, Rome, Italy.
Clin Ter. 2013;164(2):133-7. doi: 10.7417/CT.2013.1532.
In PTSD, sleep disorders represent an important symptoms dimension which is associated with more severe PTSD and increased risk of relapse. The basic treatment for PTSD is not always associated to an improvement of sleep disturbances and nightmares. Alpha-blockers, and more specifically Prazosin, have shown a specific action on sleep disorders in PTSD. We report the clinical case of a young women with PTSD, who was suffering from severe sleep disorder and distressing nightmare. The patient was treated with Terazosin, a conger of Prazosin, and has shown symptom remission. Further studies on the use of alpha-blokers might reveal new therapeutic options in PTSD.
在创伤后应激障碍（PTSD）中，睡眠障碍是一个重要的症状维度，它与更严重的PTSD以及复发风险增加相关。PTSD的基本治疗并不总是能改善睡眠障碍和噩梦。α受体阻滞剂，尤其是哌唑嗪，已显示出对PTSD睡眠障碍有特定作用。我们报告了一例患有PTSD的年轻女性临床病例，她患有严重的睡眠障碍和令人痛苦的噩梦。该患者接受了哌唑嗪同类物特拉唑嗪治疗，并出现了症状缓解。关于使用α受体阻滞剂的进一步研究可能会揭示PTSD的新治疗选择。
