Togno John, Eaton Scott
Aust Fam Physician. 2015 Sep;44(9):647-9.
Post-traumatic stress disorder (PTSD) is a common disorder with significant morbidity and associated comorbidities, including mood disorders and substance abuse, and is frequently misdiagnosed or under-diagnosed. Management of PTSD requires combined psychotherapy and pharmacotherapy, but some symptoms, particularly nightmares and sleep disturbance, are often resistant to treatment.
The aim of this article is to inform primary healthcare professionals of the prevalence and significance of PTSD, and to review the evidence that prazosin is a useful option for managing PTSD-associated nightmares and sleep disturbance.
PTSD should be considered in patients with treatment-resistant mood disorders. A trauma history should be taken for these patients and in recognised groups of patients who have a high incidence of PTSD. The treatment of PTSD is challenging, frequently requiring specialist input from psychiatrists. Prazosin has been proven to be safe and effective in the management of nightmares and sleep disturbances associated with PTSD and is indicated where these distressing symptoms are present.
创伤后应激障碍（PTSD）是一种常见疾病，具有较高的发病率以及包括情绪障碍和药物滥用在内的相关合并症，且经常被误诊或漏诊。PTSD的治疗需要心理治疗和药物治疗相结合，但某些症状，尤其是噩梦和睡眠障碍，往往对治疗有抵抗性。
本文旨在让基层医疗保健专业人员了解PTSD的患病率和重要性，并综述有关哌唑嗪是治疗PTSD相关噩梦和睡眠障碍的有效选择的证据。
对于治疗抵抗性情绪障碍患者应考虑PTSD。对于这些患者以及PTSD发病率较高的已确认患者群体，应询问其创伤史。PTSD的治疗具有挑战性，通常需要精神科医生的专业投入。哌唑嗪已被证明在治疗与PTSD相关的噩梦和睡眠障碍方面安全有效，适用于出现这些困扰症状的情况。
