在疱疹病毒感染起始时 HCF-1 对单纯疱疹病毒染色质的调节动力学。
The dynamics of HCF-1 modulation of herpes simplex virus chromatin during initiation of infection.
机构信息
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bld. 33, 33 North Drive, Bethesda, MD 20892, USA.
出版信息
Viruses. 2013 May 22;5(5):1272-91. doi: 10.3390/v5051272.
Abstract
Successful infection of herpes simplex virus is dependent upon chromatin modulation by the cellular coactivator host cell factor-1 (HCF-1). This review focuses on the multiple chromatin modulation components associated with HCF-1 and the chromatin-related dynamics mediated by this coactivator that lead to the initiation of herpes simplex virus (HSV) immediate early gene expression.
摘要
单纯疱疹病毒的成功感染依赖于细胞共激活因子-1（HCF-1）对染色质的调节。本文综述了与 HCF-1 相关的多种染色质调节成分，以及该共激活因子介导的与染色质相关的动力学，这些都导致了单纯疱疹病毒（HSV）即刻早期基因表达的启动。
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