人类促甲状腺激素β亚基（TSHB）基因的染色体区域定位

Chromosome regional mapping for the human thyroid stimulating hormone beta subunit (TSHB) gene.

作者信息

Tokino T, Hayashizaki Y, Takata K I, Yoshida M C, Matsubara K

机构信息

Institute for Molecular and Cellular Biology, Osaka University, Suita, Japan.

出版信息

Cytogenet Cell Genet. 1990;53(2-3):140-3. doi: 10.1159/000132915.

DOI:10.1159/000132915

PMID:2369842

Abstract

The human thyroid stimulating hormone beta subunit (TSHB) gene, located on chromosome 1, was studied to determine its subregional location by in situ hybridization and Southern blot analysis of human x mouse hybrid cells. The results allowed localization of TSHB to the proximal portion of 1p22, which is in the region of localization of the linkage group including amylase (AMY), nerve growth factor beta subunit (NGFB), and NRAS, which are conserved in humans and rodents.

摘要

人类促甲状腺激素β亚基（TSHB）基因位于1号染色体上，通过对人-鼠杂交细胞进行原位杂交和Southern印迹分析来研究其亚区域定位。结果将TSHB定位到1p22的近端部分，该区域是包括淀粉酶（AMY）、神经生长因子β亚基（NGFB）和NRAS在内的连锁群的定位区域，这些基因在人类和啮齿动物中是保守的。