两个受甲状腺激素调节的基因，即神经生长因子（NGFB）的β亚基和促甲状腺激素（TSHB），在人类和小鼠基因组中相距不到310千碱基对。
Two thyroid hormone regulated genes, the beta-subunits of nerve growth factor (NGFB) and thyroid stimulating hormone (TSHB), are located less than 310 kb apart in both human and mouse genomes.
作者信息
Dracopoli N C, Rose E, Whitfield G K, Guidon P T, Bale S J, Chance P A, Kourides I A, Housman D E
机构信息
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139.
出版信息
Genomics. 1988 Aug;3(2):161-7. doi: 10.1016/0888-7543(88)90148-6.
Two thyroid hormone regulated genes, the beta-subunits of nerve growth factor (NGFB) and thyroid stimulating hormone (TSHB), have been assigned to mouse chromosome 3 and human chromosome 1p22. We have used the techniques of linkage analysis and pulsed field gel electrophoresis to determine the proximity of these two antithetically regulated genes in this conserved linkage group. Four novel restriction fragment length polymorphisms were identified at the human TSHB gene. Two-point linkage analysis between TSHB and NGFB in 46 families, including the Centre d'Etude du Polymorphisme Humain (CEPH) reference panel, demonstrated no recombination (theta = 0.00, Z = 42.8). Analysis of this region by pulsed field gel electrophoresis showed that the genes for TSHB and NGFB are located less than 310 kb apart in man and 220 kb in the mouse.
两个受甲状腺激素调节的基因，即神经生长因子（NGFB）的β亚基和促甲状腺激素（TSHB），已被定位到小鼠的3号染色体和人类的1p22染色体上。我们运用连锁分析和脉冲场凝胶电泳技术，来确定在这个保守的连锁群中这两个反向调节基因的接近程度。在人类TSHB基因处鉴定出了四个新的限制性片段长度多态性。对包括人类多态性研究中心（CEPH）参考家系在内的46个家系中的TSHB和NGFB进行两点连锁分析，结果表明没有重组现象（θ = 0.00，Z = 42.8）。通过脉冲场凝胶电泳对该区域进行分析显示，在人类中TSHB和NGFB基因的间距小于310 kb，在小鼠中则为220 kb。
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