Shinozuka Kazutaka, Staples Meaghan, Borlongan Cesar V
Center of Excellence for Aging & Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA.
Int J Mol Sci. 2013 Apr 25;14(5):8924-47. doi: 10.3390/ijms14058924.
The present review paper supports the approach to deliver melatonin and to target melatonin receptors for neuroprotection in stroke. We discuss laboratory evidence demonstrating neuroprotective effects of exogenous melatonin treatment and transplantation of melatonin-secreting cells in stroke. In addition, we describe a novel mechanism of action underlying the therapeutic benefits of stem cell therapy in stroke, implicating the role of melatonin receptors. As we envision the clinical entry of melatonin-based therapeutics, we discuss translational experiments that warrant consideration to reveal an optimal melatonin treatment strategy that is safe and effective for human application.
本综述文章支持在中风中递送褪黑素并靶向褪黑素受体以实现神经保护的方法。我们讨论了实验室证据，这些证据证明了外源性褪黑素治疗以及移植分泌褪黑素的细胞在中风中的神经保护作用。此外，我们描述了干细胞疗法在中风中治疗益处背后的一种新作用机制，涉及褪黑素受体的作用。当我们设想基于褪黑素的疗法进入临床时，我们讨论了一些转化实验，这些实验值得考虑，以揭示一种对人类应用安全有效的最佳褪黑素治疗策略。
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