Department of Physiology, Faculty of Medicine, King Abdulaziz University, Jeddah, KSA.
Neuroscience Unit, Faculty of Medicine, King Abdulaziz University, Jeddah, KSA.
J Neurosci Res. 2018 Jul;96(7):1136-1149. doi: 10.1002/jnr.24220. Epub 2018 Mar 1.
Melatonin is a neurohormone secreted from the pineal gland and has a wide-ranging regulatory and neuroprotective role. It has been reported that melatonin level is disturbed in some neurological conditions such as stroke, Alzheimer's disease, and Parkinson's disease, which indicates its involvement in the pathophysiology of these diseases. Its properties qualify it to be a promising potential therapeutic neuroprotective agent, with no side effects, for some neurological disorders. This review discusses and localizes the effect of melatonin in the pathophysiology of some diseases.
褪黑素是由松果体分泌的神经激素，具有广泛的调节和神经保护作用。据报道，一些神经疾病，如中风、阿尔茨海默病和帕金森病，会导致褪黑素水平紊乱，这表明其参与了这些疾病的病理生理学过程。它的特性使其成为一些神经障碍具有潜在治疗作用的神经保护剂，且无副作用。本文讨论并定位了褪黑素在一些疾病病理生理学中的作用。
