Department of Physics, Sapienza University, 00185 Rome, Italy.
Bioinformatics. 2013 Jul 15;29(14):1821-2. doi: 10.1093/bioinformatics/btt289. Epub 2013 May 21.
The need for new drugs and new targets is particularly compelling in an era that is witnessing an alarming increase of drug resistance in human pathogens. The identification of new targets of known drugs is a promising approach, which has proven successful in several cases. Here, we describe a database that includes information on 5153 putative drug-target pairs for 150 human pathogens derived from available drug-target crystallographic complexes.
The TiPs database is freely available at http://biocomputing.it/tips.
在人类病原体的耐药性令人震惊地增加的时代，对新药和新靶标的需求尤为迫切。鉴定已知药物的新靶标是一种很有前途的方法，在许多情况下已被证明是成功的。在这里，我们描述了一个数据库，其中包含了 150 种人类病原体的 5153 对假定的药物-靶标对的信息，这些信息来自现有的药物-靶标晶体复合物。
TiPs 数据库可在 http://biocomputing.it/tips 免费获得。
Zotero 插件