Ottman R
Gertrude H. Sergievsky Center, School of Public Health, Columbia University, New York, NY 10032.
Genet Epidemiol. 1990;7(3):177-85. doi: 10.1002/gepi.1370070302.
This paper illustrates how epidemiologic principles can be used to investigate relationships between genetic susceptibility and other risk factors for disease. Five plausible models are described for relationships between genetic and environmental effects, and an example of a simple mendelian disorder that fits each model is given. Each model leads to a different set of predictions about disease risk in individuals with the genetic susceptibility alone, the risk factor alone, both, or neither. The risk predictions for the different models are described, and research designs for testing them are discussed.
本文阐述了如何运用流行病学原理来研究遗传易感性与疾病其他风险因素之间的关系。文中描述了遗传和环境效应之间关系的五种合理模型，并给出了符合每种模型的一种简单孟德尔疾病的示例。每种模型对于仅具有遗传易感性、仅具有风险因素、同时具有两者或两者皆无的个体的疾病风险会得出不同的预测结果。文中描述了不同模型的风险预测，并讨论了用于检验这些预测的研究设计。
