Zhang Xiangmin, Yu Lijiang, Wu Wei, Wu Xiuhong, Xiao Fufu, Zeng Guoxing, Lan Xiaolin
Department of Head and Neck, Ganzhou Tumor Hospital, Ganzhou 341000, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Feb;27(3):128-30, 133.
To evaluate the long-term efficacy of submandibular gland transfer for prevention of xerostomia after radiotherapy for nasopharyngeal carcinoma.
Sixty-five cases of nasopharyngeal carcinoma patients were randomly divided into study group of 32 patients and control group of 33 patents. The submandibular gland was transferred to submental region on 32 cases with nasopharyngeal carcinoma before receiving conventional radiotherapy and a block was used to cover the submental region. Before radiotherapy, two groups of submandibular gland function was detected by imaging of the submandibular gland. At 60 months after radiotherapy, submandibular gland function was detected by 99mTc radionuclide scanning, the questionnaire about the degree of xerostomia was investigated respectively. Five-year survival rate was counted.
After following up for 60 months, submandibular gland uptake and secretion function in the study group was significantly higher than that in the control group, there was significant difference between the two groups (P < 0.01) respectively. The incidence of moderate or severe xerostomia in the study group was significantly lower than that in the control group (15.4% vs 76.9%, P < 0.01). Five-year survival rate of the study group and control group was 81.3% and 78.8% respectively, there was no significant difference between the two groups (P > 0.05).
The long-term efficacy of submandibular gland transfer for prevention of xerostomia after radiotherapy for nasopharyngeal carcinoma was well. It could improve the quality of life in nasopharyngeal carcinoma patients after radiotherapy, and did not affect the long-term efficacy of nasopharyngeal carcinoma.
评估颌下腺转移术预防鼻咽癌放疗后口干症的长期疗效。
将65例鼻咽癌患者随机分为研究组32例和对照组33例。对32例鼻咽癌患者在接受常规放疗前将颌下腺转移至颏下区，并用一块组织覆盖颏下区。放疗前，通过颌下腺影像学检查检测两组颌下腺功能。放疗后60个月，通过99mTc放射性核素扫描检测颌下腺功能，分别调查口干程度问卷。计算5年生存率。
随访60个月后，研究组颌下腺摄取和分泌功能明显高于对照组，两组间差异有统计学意义（P<0.01）。研究组中、重度口干症发生率明显低于对照组（15.4%对76.9%，P<0.01）。研究组和对照组的5年生存率分别为81.3%和78.8%，两组间差异无统计学意义（P>0.05）。
颌下腺转移术预防鼻咽癌放疗后口干症的长期疗效良好。它可以提高鼻咽癌放疗后患者的生活质量，且不影响鼻咽癌的长期疗效。
