State Key Laboratory of Oncology in South China, Department of Head and Neck Surgery, Cancer Centre, Sun Yat-Sen University, Guangzhou, Guangdon, PR China.
Head Neck. 2011 Mar;33(3):389-95. doi: 10.1002/hed.21461.
Our aim in this study was to investigate the value of the submandibular salivary gland transfer procedure in prevention of radiation-induced xerostomia in patients with nasopharyngeal carcinoma (NPC).
In all, there were 70 patients, consisting of a test group (36 patients) and a control group (34 patients) in a nonrandomized fashion. In the test group, the submandibular salivary gland was transferred to submental space before radiotherapy (XRT) and shielded. Salivary gland functions were evaluated by the amount of saliva and a quality of life questionnaire before and after XRT and 3 and 60 months after XRT.
At 5 years, the trapping and excretion functions of salivary gland were significantly better in the test group (p = .000 and p = .000). The mean weight of saliva after XRT was heavier (1.65 g vs 0.73 g, p = .000), and the incidence of xerostomia was lower in the test group, with no difference in 5-year survival and neck nodal recurrence between the 2 groups.
Salivary gland transfer procedure prevents XRT-induced xerostomia and improves quality of life of patients with NPC.
本研究旨在探讨下颌下腺移位术预防鼻咽癌（NPC）患者放射性口干的价值。
共纳入 70 例患者，采用非随机分组方式分为实验组（36 例）和对照组（34 例）。实验组患者在放疗（XRT）前将下颌下腺转移至颏下间隙并加以屏蔽。通过唾液量和生活质量问卷评估放疗前后及放疗后 3 个月和 60 个月的唾液腺功能。
5 年时，实验组的唾液腺摄取和排泄功能明显更好（p =.000 和 p =.000）。XRT 后唾液的平均重量更重（1.65 g 比 0.73 g，p =.000），实验组的口干发生率较低，两组 5 年生存率和颈部淋巴结复发率无差异。
唾液腺移位术可预防 XRT 引起的口干，并提高 NPC 患者的生活质量。
