肝硬化患者发生血栓形成事件的风险。

The risk of thrombotic events in patients with liver cirrhosis.

作者信息

Gîrleanu Irina, Trifan Anca, Cojocariu Camelia, Sîngeap Ana-Maria, Sfarti C, Stanciu C

机构信息

University of Medicine and Pharmacy Grigore T Popa Iasi, Faculty of Medicine.

出版信息

Rev Med Chir Soc Med Nat Iasi. 2012 Oct-Dec;116(4):991-6.

PMID:23700877

Abstract

AIM

To evaluate the incidence and risk factors for thrombotic events (deep vein thrombosis and portal vein thrombosis) in patients with liver cirrhosis.

MATERIAL AND METHODS

we studied patients diagnosed with liver cirrhosis admitted in our department between January 2010-December 2011, which were divided in two groups: liver cirrhosis with thrombotic events and without thrombotic events.

RESULTS

we included 3108 patients, the incidence of deep vein thrombosis was 0.99% and portal vein thrombosis was 1.51%, the incidence of all thrombotic events was 2.5%. In the univariate analysis serum albumin was significantly lower in cases than controls, and MELD score, mean platelet volume were higher in cases than controls. The presence of sepsis and diabetes mellitus were demonstrated like risk factors by the univariate analysis. In multivariate analysis, albumin level< 3mg/dl (HR=1.65, CI 1.10-2.51, p=0.018) and MELD score >13 (HR=2.94, CI 1.61-5.47, p=0.001) remained independently predictive of thrombotic events.

CONCLUSIONS

The incidence of thrombotic events in patients with liver cirrhosis was 2.5%. Low serum albumin and high MELD score could predict the development of thrombotic events in patients with liver cirrhosis.

摘要

目的

评估肝硬化患者血栓形成事件（深静脉血栓形成和门静脉血栓形成）的发生率及危险因素。

材料与方法

我们研究了2010年1月至2011年12月间在我科收治的肝硬化患者，将其分为两组：有血栓形成事件的肝硬化患者和无血栓形成事件的肝硬化患者。

结果

我们纳入了3108例患者，深静脉血栓形成的发生率为0.99%，门静脉血栓形成的发生率为1.51%，所有血栓形成事件的发生率为2.5%。单因素分析显示，病例组血清白蛋白显著低于对照组，MELD评分、平均血小板体积高于对照组。单因素分析表明，脓毒症和糖尿病的存在为危险因素。多因素分析中，白蛋白水平<3mg/dl（HR=1.65，CI 1.10 - 2.51，p=0.018）和MELD评分>13（HR=2.94，CI 1.61 - 5.47，p=0.001）仍然是血栓形成事件的独立预测因素。