Vahdat Seyed Mohammad
Department of Chemistry, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.
Comb Chem High Throughput Screen. 2013 Dec;16(10):782-7. doi: 10.2174/13862073113169990003.
In the present study, Cu(II) Schiff-base complex is introduced as a highly efficient and green solid catalyst for the unsymmetrical Hantzsch condensation through a four-component coupling of various aldehydes, dimedone, ethyl acetoacetate and ammonium acetate to form polyhydroquinoline derivatives in good to excellent yields. This reaction was carried out in the presence of 1 mol% of catalysts in water at room temperature. The reusability of the catalysts was demonstrated by a five-run test. Remarkable features of this new procedure are cleaner reaction profiles, shorter reactiontimes, simple experimental and work-up procedures.
在本研究中，铜（II）席夫碱配合物被引入作为一种高效绿色的固体催化剂，用于通过各种醛、二甲基乙二酮、乙酰乙酸乙酯和醋酸铵的四组分偶联进行不对称汉茨希缩合反应，以良好至优异的产率形成多氢喹啉衍生物。该反应在室温下于水中1 mol%的催化剂存在下进行。通过五次循环测试证明了催化剂的可重复使用性。这一新方法的显著特点是反应过程更清洁、反应时间更短、实验和后处理程序简单。
