Nutritional Sciences Programme, School of Healthcare Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
J Hum Nutr Diet. 2013 Jul;26 Suppl 1:23-33. doi: 10.1111/jhn.12074. Epub 2013 May 24.
The assessment of nutritional status among paediatric patients is important for the planning and execution of nutritional strategies that strive to optimise the quality of life and growth among sick children. The present study aimed to evaluate the nutritional status and dietary intake among children with acute leukaemia.
This cross-sectional study included 53 paediatric patients aged 3-12 years old, who were diagnosed with either acute lymphoblastic leukaemia or acute myelogenous leukaemia and were undergoing chemotherapy treatments (induction or consolidation phase). Patients were matched for sex, age (±6 months) and ethnicity with healthy children as controls. Weight, height, body mass index, waist circumference, mid-upper arm circumference, triceps skinfold thickness, mid-upper arm muscle area and fat area were determined. Dietary intake was assessed using 3-day food records.
Anthropometric variables were generally higher among patients compared to controls, although the differences were not statistically significant (P > 0.05). The prevalence of overnutrition among patients according to body mass index-for-age, waist circumference-for-age, mid-upper arm circumference-for-age and triceps skinfold-for-age were 24.5%, 29.1%, 17.0% and 30.2%, respectively. Mean energy [5732 ± 1958 kJ (1370 ± 468 kcal) versus 6945 ± 1970 kJ (1660 ± 471 kcal), P < 0.01], protein (50.0 ± 19.7 g versus 62.3 ± 22.3 g, P < 0.01) and fat (43.6 ± 18.9 g versus 58.3 ± 16.7, P < 0.001) intakes of patients were significantly lower than controls.
The prevalence of being overweight and obesity in children with acute leukaemia was higher despite lower energy intake compared to controls. Studies assessing physical activity, the complex interaction and the effects of treatment drugs are warranted to better manage malnutrition among paediatric patients.
评估儿科患者的营养状况对于规划和执行营养策略非常重要，这些策略旨在优化患病儿童的生活质量和生长发育。本研究旨在评估急性白血病患儿的营养状况和饮食摄入。
本横断面研究纳入了 53 名年龄在 3-12 岁的儿科患者，他们被诊断为急性淋巴细胞白血病或急性髓细胞白血病，并正在接受化疗治疗（诱导或巩固阶段）。患者按性别、年龄（±6 个月）和种族与健康儿童相匹配作为对照组。测量体重、身高、体重指数、腰围、上臂中部周长、三头肌皮褶厚度、上臂中部肌肉区和脂肪区。通过 3 天的食物记录评估饮食摄入。
与对照组相比，患者的人体测量学变量普遍较高，但差异无统计学意义（P＞0.05）。根据体重指数-年龄、腰围-年龄、上臂中部周长-年龄和三头肌皮褶-年龄，患者的超重患病率分别为 24.5%、29.1%、17.0%和 30.2%。患者的平均能量[5732±1958 kJ（1370±468 kcal）比 6945±1970 kJ（1660±471 kcal），P＜0.01]、蛋白质（50.0±19.7 g 比 62.3±22.3 g，P＜0.01）和脂肪（43.6±18.9 g 比 58.3±16.7，P＜0.001）摄入量明显低于对照组。
尽管急性白血病患儿的能量摄入较低，但与对照组相比，超重和肥胖的患病率较高。需要评估身体活动、复杂的相互作用和治疗药物的影响等研究，以更好地管理儿科患者的营养不良。
