Department of Pathology, CHU/Université de Poitiers, Poitiers, France; Department of Radiotherapy, CHU/Université de Poitiers, Poitiers, France.
Histopathology. 2013 Jul;63(1):57-63. doi: 10.1111/his.12129. Epub 2013 May 23.
Ductal carcinoma (DC) of the prostate is an entity distinct from the common acinar cancer (AC), both on clinical and morphological aspects. We aimed to analyze the expression of molecules involved in either hormonal signalling or androgen independent pathways, in DC compared to high grade AC.
A tissue microarray was constructed with samples from 24 cases of DC and 27 cases of high grade AC. Immunohistochemistry was performed using antibodies directed against: Ki67; androgen receptor (AR); PSA; 5alpha-reductase 1, 2, 3; oestrogen receptors alpha and beta (ERA and ERB); aromatase; Alpha keto reductase 1C3; Squalene epoxidase (SQLE); BCAR1; Src. Cell proliferation and ERB staining were significantly increased in DC compared to AC. In contrast, the expressions of enzymes SQLE, aromatase, and 5 alpha reductase 2, were higher in AC. Staining for BCAR1 and Src, markers associated with androgen-independent pathways, was increased in DC compared to AC. These differences remained significant after adjusting for pTNM stage.
These results suggest that the hormone related molecular pathways that drive cancer progression might be different in AC and DC. The decrease in steroid synthesis related enzymes, together with up-regulation of the BCAR1-Src pathway, emphasizes the biological particularities of DC.
前列腺导管癌（DC）在临床和形态学方面与常见的腺泡癌（AC）不同。我们旨在分析与激素信号或雄激素非依赖性途径相关的分子在 DC 中的表达情况，并与高级别 AC 进行比较。
我们构建了一个包含 24 例 DC 和 27 例高级别 AC 样本的组织微阵列。使用针对以下抗体进行免疫组织化学染色：Ki67；雄激素受体（AR）；PSA；5α-还原酶 1、2、3；雌激素受体α和β（ERA 和 ERB）；芳香酶；α酮还原酶 1C3；鲨烯环氧化酶（SQLE）；BCAR1；Src。与 AC 相比，DC 中的细胞增殖和 ERB 染色显著增加。相比之下，AC 中 SQLE、芳香酶和 5α 还原酶 2 的表达更高。与雄激素非依赖性途径相关的标志物 BCAR1 和 Src 的染色在 DC 中也比 AC 中增加。这些差异在调整 pTNM 分期后仍然显著。
这些结果表明，推动癌症进展的与激素相关的分子途径在 AC 和 DC 中可能不同。类固醇合成相关酶的减少，加上 BCAR1-Src 途径的上调，强调了 DC 的生物学特殊性。
