Zou Yuheng, Zhang Hongying, Bi Feng, Tang Qiulin, Xu Huanji
Department of Medical Oncology, Cancer Center and Laboratory of Molecular Targeted Therapy in Oncology, West China Hospital, Sichuan University, Chengdu, China.
Laboratory of Oncogene, West China Hospital, Sichuan University, Chengdu, China.
Front Oncol. 2022 Aug 24;12:938502. doi: 10.3389/fonc.2022.938502. eCollection 2022.
Cholesterol metabolism is often dysregulated in cancer. Squalene monooxygenase (SQLE) is the second rate-limiting enzyme involved in cholesterol synthesis. Since the discovery of SQLE dysregulation in cancer, compelling evidence has indicated that SQLE plays a vital role in cancer initiation and progression and is a promising therapeutic target for cancer treatment. In this review, we provide an overview of the role and regulation of SQLE in cancer and summarize the updates of antitumor therapy targeting SQLE.
胆固醇代谢在癌症中常常失调。角鲨烯单加氧酶（SQLE）是参与胆固醇合成的第二个限速酶。自发现癌症中SQLE失调以来，有力证据表明SQLE在癌症的起始和进展中起着至关重要的作用，并且是癌症治疗中一个有前景的治疗靶点。在本综述中，我们概述了SQLE在癌症中的作用和调控，并总结了靶向SQLE的抗肿瘤治疗的进展。
