醛固酮合成酶基因（CYP11B2）-344C/T多态性与复发性脑缺血风险相关。
Aldosterone synthase gene (CYP11B2) -344C/T polymorphism contributes to the risk of recurrent cerebral ischemia.
作者信息
Ji Peng, Jiang Limin, Zhang Shuling, Cui Wei, Zhang Daopei, Fu Shengqi, Zhang Hongtao
机构信息
Department of Neurology-Muscle, Brain Hospital of People's Hospital of Zhengzhou, Henan Province, China.
出版信息
Genet Test Mol Biomarkers. 2013 Jul;17(7):548-52. doi: 10.1089/gtmb.2013.0026. Epub 2013 May 23.
BACKGROUND
Accumulating evidence suggests that CYP11B2 rs1799998 (-344C/T) polymorphism is independently associated with an increased risk of stroke. Our aim was to determine whether -344C/T also predisposes to recurrent cerebral ischemia following in patients with symptomatic intracranial atherosclerosis disease (ICAD).
METHODS
Genotypes of the CYP11B2 -344C/T polymorphism were determined by polymerase chain reaction-restriction fragment length polymorphism. A total of 208 ICAD patients were enrolled and underwent a long-term clinical follow-up to detect the recurrent cerebral ischemia.
RESULTS
During a median follow-up time of 35 months, 40 recurrent strokes (19.2%) were documented. Kaplan-Meier and multivariable Cox regression analyses adjusted for age, gender, and other cardiovascular risk factors identified that the presence of the TT genotype within the CYP11B2 -344C/T polymorphism was associated with an increased risk of 1.98-fold for recurrent cerebral ischemia (the hazard ratio 1.98, 95% confidence interval 1.16-3.41; p=0.01).
CONCLUSIONS
Our findings suggest that the -344C/T polymorphism of the CYP11B2 gene confers an increased risk of recurrent cerebral ischemia.
背景
越来越多的证据表明，CYP11B2基因rs1799998（-344C/T）多态性与中风风险增加独立相关。我们的目的是确定-344C/T多态性是否也会使有症状的颅内动脉粥样硬化疾病（ICAD）患者发生复发性脑缺血的风险增加。
方法
采用聚合酶链反应-限制性片段长度多态性方法检测CYP11B2基因-344C/T多态性的基因型。共纳入208例ICAD患者，并进行长期临床随访以检测复发性脑缺血。
结果
在中位随访时间35个月期间，记录到40例复发性中风（19.2%）。经年龄、性别和其他心血管危险因素校正的Kaplan-Meier和多变量Cox回归分析确定，CYP11B2基因-344C/T多态性中TT基因型的存在与复发性脑缺血风险增加1.98倍相关（风险比1.98，95%置信区间1.16-3.41；P=0.01）。
结论
我们的研究结果表明，CYP11B2基因的-344C/T多态性会增加复发性脑缺血的风险。
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