Yu Yang
Department of Neurosurgery, Zhejiang Cancer Hospital, Hangzhou, China
J Renin Angiotensin Aldosterone Syst. 2015 Jun;16(2):382-8. doi: 10.1177/1470320313492362. Epub 2013 Jun 7.
The CYP11B2 gene has been suggested to play an important role in the pathogenesis of ischemic stroke. However, the results have been inconsistent. In this study, we performed a meta-analysis to clarify the association of the CYP11B2 -344C/T variant with ischemic stroke.
Published literature from PubMed and Embase were retrieved. Pooled odds ratio with 95% confidence interval was calculated using a fixed- or random-effects model. A total of seven studies (2765 stroke cases and 3118 controls) for the CYP11B2 -344C/T variant were included in the meta-analysis.
The meta-analysis indicated that the CYP11B2 -344C/T variant was significantly associated with ischemic stroke under a homogeneous co-dominant model (TT vs. CC: odds ratio=2.04, 95% confidence interval=1.21-3.45), dominant model (TT+TC vs. CC: odds ratio=1.67, 95% confidence interval=1.09-2.57) and recessive model (TT vs. TC+CC: odds ratio=1.56, 95% confidence interval=1.18-2.05) but not under a heterogeneous co-dominant model (TC vs. CC: odds ratio=1.43, 95% confidence interval=0.98-2.07). Further subgroup analysis showed that the CYP11B2 -344C/T variant was significantly associated with ischemic stroke in East Asian and South Asian populations, but not in a Caucasian population.
The present meta-analysis supported the positive association of the CYP11B2 -344C/T variant with ischemic stroke. Further large-scale studies considering gene-gene/gene-environment interactions should be conducted to investigate the association.
已有研究表明CYP11B2基因在缺血性中风的发病机制中起重要作用。然而，研究结果并不一致。在本研究中，我们进行了一项荟萃分析，以阐明CYP11B2基因-344C/T变异与缺血性中风之间的关联。
检索了来自PubMed和Embase的已发表文献。使用固定效应模型或随机效应模型计算合并比值比及95%置信区间。本荟萃分析共纳入了7项关于CYP11B2基因-344C/T变异的研究（2765例中风病例和3118例对照）。
荟萃分析表明，在同质共显性模型（TT与CC相比：比值比=2.04，95%置信区间=1.21-3.45）、显性模型（TT+TC与CC相比：比值比=1.67，95%置信区间=1.09-2.57）和隐性模型（TT与TC+CC相比：比值比=1.56，95%置信区间=1.18-2.05）下，CYP11B2基因-344C/T变异与缺血性中风显著相关，但在异质共显性模型（TC与CC相比：比值比=1.43，95%置信区间=0.98-2.07）下无显著相关性。进一步的亚组分析表明，CYP11B2基因-344C/T变异与东亚和南亚人群的缺血性中风显著相关，但与高加索人群无关。
本荟萃分析支持CYP11B2基因-344C/T变异与缺血性中风呈正相关。应开展进一步的大规模研究，考虑基因-基因/基因-环境相互作用，以研究这种关联。
