Key Laboratory of Marine Bio-resources Sustainable Utilization/Guangdong Key Laboratory of Marine Material Medical/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, People's Republic of China.
J Nat Prod. 2013 May 24;76(5):983-7. doi: 10.1021/np400132m. Epub 2013 Apr 26.
Two new benzodiazepine alkaloids, circumdatins K and L (1, 2), two new prenylated indole alkaloids, 5-chlorosclerotiamide (3) and 10-epi-sclerotiamide (4), and one novel amide, aspergilliamide B (5), together with six known alkaloids were isolated from the deep-sea-derived fungus Aspergillus westerdijkiae DFFSCS013. Their structures were elucidated by extensive spectroscopic analysis. All of the compounds were tested for cytotoxicity toward human carcinoma A549, HL-60, K562, and MCF-7 cell lines.
从深海来源真菌 Aspergillus westerdijkiae DFFSCS013 中分离得到两个新的苯并二氮杂卓生物碱（1、2），circumdatins K 和 L，两个新的烯丙基吲哚生物碱，5-氯麦角硫因酰胺（3）和 10-表麦角硫因酰胺（4），以及一个新的酰胺，aspergilliamide B（5），以及六个已知的生物碱。通过广泛的光谱分析阐明了它们的结构。所有化合物均对人癌细胞 A549、HL-60、K562 和 MCF-7 细胞系进行了细胞毒性测试。
