海洋来源真菌作为具有多样结构的生物活性吲哚生物碱的来源。
Marine-derived fungi as a source of bioactive indole alkaloids with diversified structures.
作者信息
Meng Zhi-Hui, Sun Tian-Tian, Zhao Guo-Zheng, Yue Yu-Fei, Chang Qing-Hua, Zhu Hua-Jie, Cao Fei
机构信息
College of Pharmaceutical Sciences, Institute of Life Science and Green Development, Hebei University, Baoding, 071002 China.
出版信息
Mar Life Sci Technol. 2020 Nov 24;3(1):44-61. doi: 10.1007/s42995-020-00072-w. eCollection 2021 Feb.
Abstract
Marine-derived fungi are well known as rich sources of bioactive natural products. Growing evidences indicated that indole alkaloids, isolated from a variety of marine-derived fungi, have attracted considerable attention for their diverse, challenging structural complexity and promising bioactivities, and therefore, indole alkaloids have potential to be pharmaceutical lead compounds. Systemic compilation of the relevant literature. In this review, we demonstrated a comprehensive overview of 431 new indole alkaloids from 21 genera of marine-derived fungi with an emphasis on their structures and bioactivities, covering literatures published during 1982-2019.
摘要
海洋来源的真菌是众所周知的丰富生物活性天然产物来源。越来越多的证据表明，从多种海洋来源真菌中分离出的吲哚生物碱因其多样、具有挑战性的结构复杂性和有前景的生物活性而备受关注，因此，吲哚生物碱有潜力成为药物先导化合物。对相关文献进行系统汇编。在本综述中，我们全面概述了来自21个海洋来源真菌属的431种新吲哚生物碱，重点介绍了它们的结构和生物活性，涵盖了1982年至2019年期间发表的文献。
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