Institute of Pathology, University of Ulm, Ulm, Germany.
J Microsc. 2013 Jul;251(1):84-98. doi: 10.1111/jmi.12048. Epub 2013 May 23.
This paper deals with the estimation of the intensity of a planar point process on the basis of a single point pattern, observed in a rectangular window. If the model assumptions of stationarity and isotropy hold, the method of block bootstrapping can be used to estimate the intensity of the process with confidence bounds. The results of two variants of block bootstrapping are compared with a parametric approximation based on the assumption of a Gaussian distribution of the numbers of points in deterministic subwindows of the original pattern. The studies were performed on patterns obtained by simulation of well-known point process models (Poisson process, two Matérn cluster processes, Matérn hardcore process, Strauss hardcore process). They were also performed on real histopathological data (point patterns of capillary profiles of 12 cases of prostatic cancer). The methods are presented as worked examples on two cases, where we illustrate their use as a check on stationarity (homogeneity) of a point process with respect to different fields of vision. The paper concludes with various methodological discussions and suggests possible extensions of the block bootstrap approach to other fields of spatial statistics.
本文基于在矩形窗口中观察到的单个点模式,讨论了平面点过程强度的估计问题。如果满足平稳性和各向同性的模型假设,则可以使用块自举法来估计过程的强度,并带有置信区间。两种块自举法的结果与基于原始模式中确定的子窗口内点数的正态分布假设的参数逼近进行了比较。研究是在模拟著名点过程模型(泊松过程、两个 Matérn 簇过程、Matérn 核过程、Strauss 核过程)得到的模式上进行的。还对真实的组织病理学数据(12 例前列腺癌的毛细血管轮廓点模式)进行了研究。该方法在两个案例中被呈现为实际示例,我们说明了它们如何用作针对不同视野的点过程平稳性(同质性)的检查。本文最后进行了各种方法学讨论,并提出了将块自举方法扩展到其他空间统计领域的可能方法。