ISREC - Swiss Institute for Experimental Cancer Research, National Center of Competence for Molecular Oncology, School of Life Sciences, Ecole polytechnique fédérale de Lausanne (EPFL), SV2.832 Station 19, CH-1015 Lausanne, Switzerland.
Nat Rev Cancer. 2013 Jun;13(6):385-96. doi: 10.1038/nrc3518.
Understanding the biology of the breast and how ovarian hormones impinge on it is key to rational new approaches in breast cancer prevention and therapy. Because of the success of selective oestrogen receptor modulators (SERMs), such as tamoxifen, and aromatase inhibitors in breast cancer treatment, oestrogens have long received the most attention. Early progesterone receptor (PR) antagonists, however, were dismissed because of severe side effects, but awareness is now increasing that progesterone is an important hormone in breast cancer. Oestrogen receptor-α (ERα) signalling and PR signalling have distinct roles in normal mammary gland biology in mice; both ERα and PR delegate many of their biological functions to distinct paracrine mediators. If the findings in the mouse model translate to humans, new preventive and therapeutic perspectives might open up.
了解乳房的生物学特性以及卵巢激素对其的影响是制定乳腺癌预防和治疗新方法的关键。由于选择性雌激素受体调节剂（SERMs）如他莫昔芬和芳香酶抑制剂在乳腺癌治疗中的成功，雌激素一直受到最多的关注。然而，由于早期孕激素受体（PR）拮抗剂存在严重的副作用而被摒弃，但现在人们越来越意识到孕激素是乳腺癌的一种重要激素。在小鼠中，雌激素受体-α（ERα）信号和孕激素受体信号在正常乳腺生物学中具有不同的作用；ERα 和 PR 都将其许多生物学功能委托给不同的旁分泌介质。如果在小鼠模型中的发现可以转化到人类身上，那么可能会开辟新的预防和治疗视角。
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