Cancer Research Program, Garvan Institute, Sydney, NSW, Australia.
Mol Cell Endocrinol. 2012 Jun 24;357(1-2):101-7. doi: 10.1016/j.mce.2011.09.020. Epub 2011 Sep 16.
Progesterone and prolactin remodel mammary morphology during pregnancy by acting on the mammary epithelial cell hierarchy. The roles of each hormone in mammary development have been well studied, but evidence of signalling cross-talk between progesterone and prolactin is still emerging. Factors such as receptor activator of NFkB ligand (RANKL) may integrate signals from both hormones to orchestrate their joint actions on the epithelial cell hierarchy. Common targets of progesterone and prolactin signalling are also likely to integrate their pro-proliferative actions in breast cancer. Therefore, a thorough understanding of the interplay between progesterone and prolactin in mammary development may reveal therapeutic targets for breast cancer. This review summarises our understanding of Pg and PRL action in mammary gland development before focusing on molecular mechanisms of signalling cross-talk and the implications for breast cancer.
孕激素和催乳素通过作用于乳腺上皮细胞层级来重塑怀孕期的乳腺形态。每种激素在乳腺发育中的作用都得到了很好的研究，但孕激素和催乳素之间信号交叉对话的证据仍在不断涌现。核因子-κB 受体激活剂配体（RANKL）等因素可能整合来自两种激素的信号，以协调它们对上皮细胞层级的联合作用。孕激素和催乳素信号的共同靶标也可能整合它们在乳腺癌中的促增殖作用。因此，深入了解孕激素和催乳素在乳腺发育中的相互作用可能为乳腺癌揭示治疗靶点。本综述总结了我们对乳腺发育中 Pg 和 PRL 作用的理解，然后重点介绍信号交叉对话的分子机制及其对乳腺癌的影响。
