年龄相关性黄斑变性的免疫学。
Immunology of age-related macular degeneration.
机构信息
Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky 40506, USA.
出版信息
Nat Rev Immunol. 2013 Jun;13(6):438-51. doi: 10.1038/nri3459.
Abstract
Age-related macular degeneration (AMD) is a leading cause of blindness in aged individuals. Recent advances have highlighted the essential role of immune processes in the development, progression and treatment of AMD. In this Review we discuss recent discoveries related to the immunological aspects of AMD pathogenesis. We outline the diverse immune cell types, inflammatory activators and pathways that are involved. Finally, we discuss the future of inflammation-directed therapeutics to treat AMD in the growing aged population.
摘要
年龄相关性黄斑变性（AMD）是老年人致盲的主要原因。最近的研究进展强调了免疫过程在 AMD 发病机制中的发展、进展和治疗中的重要作用。在这篇综述中，我们讨论了与 AMD 发病机制的免疫学方面相关的最新发现。我们概述了涉及的不同免疫细胞类型、炎症激活物和途径。最后，我们讨论了针对 AMD 进行炎症靶向治疗的未来，以满足不断增长的老年人口的需求。
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本文引用的文献
1
Targeted intraceptor nanoparticle therapy reduces angiogenesis and fibrosis in primate and murine macular degeneration.
ACS Nano. 2013 Apr 23;7(4):3264-75. doi: 10.1021/nn305958y. Epub 2013 Mar 20.
2
Inflammatory mediators induced by amyloid-beta in the retina and RPE in vivo: implications for inflammasome activation in age-related macular degeneration.
Invest Ophthalmol Vis Sci. 2013 Mar 1;54(3):2225-37. doi: 10.1167/iovs.12-10849.
3
Seven new loci associated with age-related macular degeneration.
Nat Genet. 2013 Apr;45(4):433-9, 439e1-2. doi: 10.1038/ng.2578. Epub 2013 Mar 3.
4
Suppression of laser-induced choroidal neovascularization by a CCR3 antagonist.
Invest Ophthalmol Vis Sci. 2013 Feb 28;54(2):1564-72. doi: 10.1167/iovs.11-9095.
5
Pharmacogenetics for genes associated with age-related macular degeneration in the Comparison of AMD Treatments Trials (CATT).
Ophthalmology. 2013 Mar;120(3):593-599. doi: 10.1016/j.ophtha.2012.11.037. Epub 2013 Jan 18.
6
Subretinal drusenoid deposits in non-neovascular age-related macular degeneration: morphology, prevalence, topography, and biogenesis model.
Retina. 2013 Feb;33(2):265-76. doi: 10.1097/IAE.0b013e31827e25e0.
7
NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration.
Invest Ophthalmol Vis Sci. 2013 Jan 7;54(1):110-20. doi: 10.1167/iovs.12-10655.
8
New biomarker for neovascular age-related macular degeneration: eotaxin-2.
DNA Cell Biol. 2012 Nov;31(11):1618-27. doi: 10.1089/dna.2012.1786. Epub 2012 Oct 1.
9
Association of genetic variants on 8p21 and 4q12 with age-related macular degeneration in Asian populations.
Invest Ophthalmol Vis Sci. 2012 Sep 25;53(10):6576-81. doi: 10.1167/iovs.12-10219.
10
Cumulative effect of risk alleles in CFH, ARMS2, and VEGFA on the response to ranibizumab treatment in age-related macular degeneration.
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