Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky 40506, USA.
Nat Rev Immunol. 2013 Jun;13(6):438-51. doi: 10.1038/nri3459.
Age-related macular degeneration (AMD) is a leading cause of blindness in aged individuals. Recent advances have highlighted the essential role of immune processes in the development, progression and treatment of AMD. In this Review we discuss recent discoveries related to the immunological aspects of AMD pathogenesis. We outline the diverse immune cell types, inflammatory activators and pathways that are involved. Finally, we discuss the future of inflammation-directed therapeutics to treat AMD in the growing aged population.
年龄相关性黄斑变性（AMD）是老年人致盲的主要原因。最近的研究进展强调了免疫过程在 AMD 发病机制中的发展、进展和治疗中的重要作用。在这篇综述中，我们讨论了与 AMD 发病机制的免疫学方面相关的最新发现。我们概述了涉及的不同免疫细胞类型、炎症激活物和途径。最后，我们讨论了针对 AMD 进行炎症靶向治疗的未来，以满足不断增长的老年人口的需求。
